摘要 :
The present paper reports a clinical observation of the effect of health-preserving moxibustion in the aged people without apparent organic diseases. Results show that the health-preserving moxibustion has an evident action in les...
展开
The present paper reports a clinical observation of the effect of health-preserving moxibustion in the aged people without apparent organic diseases. Results show that the health-preserving moxibustion has an evident action in lessening aging symptoms and improving physiologic functions of the senile body. It is held in traditional Chinese medicine that from the middle-aged period on, the decline of kidney Qi is an important cause of senility and deficiency of the spleen and blood stasis also play a role in some degree. Health-preserving moxibustion of Shenque and Zusanli has actions in warming Yang, reinforcing Qi and promoting blood circulation to remove obstruction in meridians. It is thus a method for self health protection.
收起
摘要 :
The purpose of this study was to analyze the differences of determinants and intention to enter the facility in the subjects with middle-aged (40-60 years old) and senile generations (over 60 years old) in China. 320 data for the ...
展开
The purpose of this study was to analyze the differences of determinants and intention to enter the facility in the subjects with middle-aged (40-60 years old) and senile generations (over 60 years old) in China. 320 data for the senile generation and 305 for middle-aged generation were used as the final analysis. For the determinants to enter the facility, the image of the facility was the most influential variable in both generations. It is necessary to consider the image of the facility was the important reason for the middle-aged generation not to enter the facility despite no difference on the image of the facility between the groups.
收起
摘要 :
Abstract Direct replacement of decreased ceramides in the stratum corneum can be efficacious for skin hydration, skin barrier function, and skin pH. Our study aimed to evaluate the 24‐hr, 28‐day, and 7‐day post‐moisturizing ef...
展开
Abstract Direct replacement of decreased ceramides in the stratum corneum can be efficacious for skin hydration, skin barrier function, and skin pH. Our study aimed to evaluate the 24‐hr, 28‐day, and 7‐day post‐moisturizing efficacy of ceramide‐containing moisturizer in senile xerosis treatment. A split site, double‐blinded, randomized, controlled study was conducted in 24 senile subjects (91.7% females, mean age 54.83?±?5.45?years) with mild to moderate xerosis, who were randomized to receive ceramide‐containing moisturizer or hydrophilic cream, daily applied on each side of the shin. A single application of ceramide‐containing moisturizer increased skin hydration, while improving transepidermal water loss (TEWL) and skin pH for up to 24?hr, with statistically significant difference. After 28?days of twice‐daily application, more significant improvement on skin hydration, barrier function, and skin pH was observed in those with ceramide‐containing moisturizer at all‐time points. At day 28, there was a statistically significant decrease of hemoglobin index, wrinkle, and texture on the ceramide treated side. The 7‐day post‐moisturizing efficacy on the ceramide treated side was superior for skin hydration, TEWL, skin pH, and wrinkle. Thus, the ceramide‐containing moisturizer can be a novel promising treatment for senile xerosis.
收起
摘要 :
This paper summarizes the present knowledge of aging in melanocytes in vivo and in vitro and age-related hypo- and hyper-pigmented diseases. In the aged skin, focal hypo-and hyper-pigmentation (solar lentigo) is often found. Appar...
展开
This paper summarizes the present knowledge of aging in melanocytes in vivo and in vitro and age-related hypo- and hyper-pigmented diseases. In the aged skin, focal hypo-and hyper-pigmentation (solar lentigo) is often found. Apparently this results from progressive loss of active melanocytes and focal increase in melanocyte proliferation and/or aggregation. From a decrease of normal pigmentation during wound healing or after sunlight exposure, it is suggested that the number of active melanocytes decrease in aged people.
收起
摘要 :
Two fractions of esterase were partially purified from the soluble fraction of normal human lens. The apparent molecular masses of these enzymes were approximately 200 kDa (esterase-I) and 30 kDa (csterase-II). The optimal pH of e...
展开
Two fractions of esterase were partially purified from the soluble fraction of normal human lens. The apparent molecular masses of these enzymes were approximately 200 kDa (esterase-I) and 30 kDa (csterase-II). The optimal pH of esterase-I and esterase-II was 6.0 and 7.5, and their respective optimal temperature were 43 °C and 46°C. The Km values of esterase-I and esterase-II for 4-niethylumbeIliferyl-palniitate were 0.14 and 0.11 /im, respectively. The activity of these enzymes was inhibited by EDTA. The fraction with esterase activity also displayed lipase activity, although it is unknown whether the two enzymes are identical. Variation in the activity of these csterases was examined as a function of age for normal lens and as functions of age and coloration for senile cataractous lenses. The normal lenses maintained high enzyme activity up to the 60 age group and their enzyme activity then fell abruptly. In the senile cataractous lenses, enzyme activity was very low as compared to that of normal lenses of similar age. This shows that cataract formation may have a deleterious effect on the catalytic activity of esterase in the lens.
收起
摘要 :
INTRODUCTION: Cerebral arterial, venous and cerebrospinal fluid (CSF) pulsations are closely coupled and this produces pulsation dampening or the windkessel effect. Normal pressure hydrocephalus is a manifestation of the breakdown...
展开
INTRODUCTION: Cerebral arterial, venous and cerebrospinal fluid (CSF) pulsations are closely coupled and this produces pulsation dampening or the windkessel effect. Normal pressure hydrocephalus is a manifestation of the breakdown of this windkessel effect with altered CSF and venous pulsations being noted. The aim of this study was to show that dysfunction of the windkessel mechanism is also a component of normal aging and senile dementia. METHODS: The study group comprised 24 patients classified as either early senile dementia of Alzheimer's type (SDAT) or vascular dementia (VaD). The patients with dementia were compared with 12 age-matched non-cognitively impaired subjects, and 12 normal young individuals were compared with the normal aging group. MRI flow quantification was used to measure the nonpulsatile and pulsatile components of blood flow as well as the pulsation at the tentorial incisura. RESULTS: With normal aging blood flow decreased but arterial pulsations increased in volume by 49% (P = 0.003). The CSF vented via the tentorial incisura does not change significantly with age and therefore increased venous pulsation is necessary. In patients with VaD the arterial pulse volume was higher by 24% and the straight sinus pulsation was higher by 57% than in normal aging subjects (P = 0.05 and P = 0.03, respectively). In patients with SDAT the total venous pulsation volumes were similar to those in normal aging subjects but there was less basal sinus pulsation. CONCLUSION: Normal aging, SDAT and VaD are associated with alterations in venous pulsation due to a breakdown of the windkessel effect.
收起
摘要 :
More than half of all subjects with chronic heart failure are older adults with preserved ejection fraction (HFpEF). Effective therapy for this condition is yet to be delineated by clinical trials, suggesting that a greater unders...
展开
More than half of all subjects with chronic heart failure are older adults with preserved ejection fraction (HFpEF). Effective therapy for this condition is yet to be delineated by clinical trials, suggesting that a greater understanding of underlying biologic mechanisms is needed, especially for the purpose of clinical intervention and future clinical trials. Amyloid infiltration of the myocardium is an underappreciated contributing factor to HFpEF that is often caused by misfolded monomers or oligomers of the protein transthyretin. While previously called senile cardiac amyloidosis and traditionally requiring endomyocardial biopsy for diagnosis, advances in our pathophysiologic understanding of this condition, coupled with nuclear imaging techniques using bone isotopes that can diagnose this condition noninvasively and the development of potential therapies, have resulted in a renewed interest in this previously considered "rare" condition. This reviewer focuses on the re-emergence of nuclear cardiology using pyrophosphate agents that hold promise for early, noninvasive identification of affected individuals. (C) 2015 Elsevier Inc. All rights reserved.
收起
摘要 :
Aim. To study the role of hepcidin as a regulator of iron metabolism and a mediator of inflammation in elderly and senile patients with chronic heart failure (CHF) with anemia of chronic diseases (ACD). Material and methods. The l...
展开
Aim. To study the role of hepcidin as a regulator of iron metabolism and a mediator of inflammation in elderly and senile patients with chronic heart failure (CHF) with anemia of chronic diseases (ACD). Material and methods. The levels of hemogram parameters, ferrokinetics (serum iron, ferritin, transferrin, erythropoietin, hepcidin), inflammation [C-reactive protein (CRP), interleukin-6 (IL-6)], as well as correlations between hepcidin and these parameters were studied in patients with CHF with ACD (n=35), with CHF without anemia (n=35) and in elderly and senile patients without CHF and anemia (control group; n=20). Results. Normal levels of hepcidin (9.17±0.97 ng/ml) and the only significant correlation of hepcidin with the ferrokinetic parameter – serum iron [r(S)=0.480, p<0.05] were found in the control group. Normal levels of hepcidin (12.01±1.19 ng/ml) and two significant correlations of hepcidin with the ferrokinetic parameter – ferritin [r(S)=0.525, p<0.05] and transferrin [r(S)=-0.343, p<0.05] were found in the CHF without anemia group. Significantly elevated levels of hepcidin (23.81±3.63 ng/ml) were found in the CHF with ACD group compared to the CHF without anemia group (p=0.008) and the control group (p=0.003). Also, five significant correlations of hepcidin with hemogram parameters – hemoglobin [r(S)=-0.461, p<0.05] and the average concentration of hemoglobin in the erythrocyte [r(S)=-0.437, p<0.05]; with ferrokinetic parameters – ferritin [r(S)=0.596,p<0.05] and transferrin [r(S)=-0.474, p<0.05]; with inflammation parameters – CRP [r(S)=0.561, p<0.05] were found in the CHF with ACD group. Conclusion. The increased level of hepcidin in CHF patients with ACD and the formation of links of hepcidin with indicators of inflammation reflect its role as a mediator of inflammation, and the formation of connections with indicators of hemogram and ferrokinetics – its role as a regulator of iron metabolism involved in the development of ACD in elderly and senile CHF patients.
收起
摘要 :
Background Anorexia of ageing (AA) may be considered as a risk factor for frailty and has an important impact on quality of life, morbidity and mortality. Methods A systematic review and a meta-analysis were performed to summarise...
展开
Background Anorexia of ageing (AA) may be considered as a risk factor for frailty and has an important impact on quality of life, morbidity and mortality. Methods A systematic review and a meta-analysis were performed to summarise the results from several trials on the effectiveness of treatments in AA, as associated with depression, sensory impairment of taste and smell, decreased appetite or early satiety, and disability. Eligible studies were required to report baseline and follow-up values, the mean change ( increment -change) from baseline, and/or the mean difference among intervention groups versus control group, concerning food intake (kcal/daily) and/or nutritional outcomes, such as body weight, body mass index, albumin and Mini Nutritional Assessment. Results The systematic review included 20 papers based on different therapeutic approaches concerning food intake and/or nutritional outcomes. The results of the meta-analysis indicate that the interventions for AA have an important impact on body weight [+1.59 kg; 95% confidence interval (CI) = 1.48-+1.71 kg; P < 0.001) and on energy intake (+56.09 kcal; 95% CI = -54.05 to +166.25 kcal; P = 0.32). Regarding secondary outcomes, it was not possible to meta-analyse the limited amount of data availab le. Conclusions The different variants of AA need to be defined because diverse therapeutic approaches are available. A more precise definition of the functional impairments associated with AA may allow a more correct decision about the most appropriate therapy to be prescribed. Moreover, this may allow for a more effective performance of the different therapeutic approaches once they are better targeted to the different scenarios of AA.
收起
摘要 :
BACKGROUND: Coronary allograft vasculopathy is a severe complication of heart transplantation. We used virtual histology intravascular ultrasound to characterize plaque burden and tissue composition over time in heart transplant r...
展开
BACKGROUND: Coronary allograft vasculopathy is a severe complication of heart transplantation. We used virtual histology intravascular ultrasound to characterize plaque burden and tissue composition over time in heart transplant recipients. METHODS: We recruited patients undergoing heart transplantation in four centers in Europe and the US between 2004 and 2006. We used intravascular ultrasound to obtain morphological plaque measurements and to perform virtual histology in the left anterior descending coronary artery. Data were characterized according to the duration between transplantation and intravascular ultrasound assessment: 24-60, >60-120 and >120-192 months. RESULTS: We assessed vessels from 152 patients (mean age 58 +/- 12 years) a mean of 70 +/- 53 months (range 1 week to 16 years) after transplantation. Plaque burden of >40% was observed in 26% of vessels analyzed, with increases from baseline being seen in all time categories. If assessed >24 months after transplantation, necrotic core and dense calcified volumes were significantly greater than at baseline (P = 0.0005 and P = 0.01, respectively). Time since heart transplantation and donor age and recipient age were independent predictive factors of increased necrotic core content. Necrotic core volume >2.01 mm(3), diabetes mellitus, donor age older than 40 years, follow-up from transplantation longer than 5 years and recipient age older than 58 years were associated with the need for revascularization. CONCLUSIONS: In coronary allograft vasculopathy, plaque burden and composition change over time and seem to affect clinical outcome. This relationship might facilitate identification of high-risk patients in whom the value of more aggressive medical therapy should be tested.
收起
原文获取